Thrombin microcapsules, preparation and uses thereof

A method for preparing thrombin microcapsules, the method comprising the step of:

• a) spray drying an aqueous solution comprising:
• i) thrombin at a concentration ranging from 100 to 3000 IU/ml,
• ii) a carrier protein at a concentration ranging from 0.6 to 60 mg/ml and
• iii) a carbohydrate at a concentration ranging from 2 to 200 mg/ml,
• wherein said spray drying comprises producing droplets from the solution, and evaporating water from the droplets, wherein said evaporating is carried out by a drying gas and comprises heating said gas to a temperature ranging from about 100 to 170° C., thereby obtaining the thrombin microcapsules;
• and
• b) cooling the thrombin microcapsules by exposure to a cold gas flow.