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US 10,869,908 B2Granted
Inducing cell death by hyperactivation of motility networks
AssigneeThe Johns Hopkins University
InventorsPeter Devreotes, Huaqing Cai, Marc Edwards, Jun Liu, Michele Vitolo, Thomas Lampert, Yu Long, Alexandra Debonnes
Life of this patent
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Abstract
Methods of inducing cell death by hyperactivation of motility networks are provided.
Claims21
A method of killing a cell with an activated motility network comprising:
- stressing the cell or further activating or hyper-activating the cell's motility network,
- wherein an agent or stressor is administered to the cell thereby selectively killing the cell, wherein the cell bears a mutated oncogene or mutated tumor suppressor gene, wherein the mutated gene comprises Ras, PI3K, PTEN, or another defined mutation that activates a cell migration pathway, and the agent or stressor comprises an environmental perturbation.
A method of killing a cell comprising:
- administering to a cell an agent or stressor that selectively kills the cell, wherein the cell bears a mutated oncogene or mutated tumor suppressor gene, wherein the mutated gene comprises Ras, PI3K, PTEN, or another defined mutation that activates a cell migration pathway, and the agent or stressor comprises an environmental perturbation.
A method of killing a cell, comprising:
- treating the cell with an environmental perturbation that selectively kills the cell, wherein the cell bears a mutated oncogene or mutated tumor suppressor gene, wherein the mutated gene comprises Ras, PI3K, PTEN, or another defined mutation that activates a cell migration pathway.
Dependencies are inferred from the claim text.