US 10,869,907 B2Granted

Implantable meshes for controlling the movement of fluids

AssigneeArch Biosurgery, Inc.

InventorsTerrence Norchi, Steven Kates, Rutledge Ellis-Behnke

Life of this patent

Estimating the term…

Loading patent…

Abstract

Meshes for use to control the movement of bodily fluids, such as blood, are described herein. The mesh can be partially or completely biodegradable or non-biodegradable. In one embodiment, the mesh is formed from one or more self-assembling peptides. The peptides can be in the form of fibers, such as nanofibers. The peptides can be assembled prior to formation of the mesh or after the mesh has been formed but before it is applied. Alternatively, the mesh can be prepared from unassembled peptides, which assemble at the time of application. The peptides can assemble upon contact with bodily fluids (e.g., blood) or can be contacted with an ionic solution to initiate assembly.

Claims26

Dependent claims

A wound dressing formed from woven or non-woven fibers of self-assembling peptides,

wherein the self-assembling peptides comprise a sequence of amino acid residues conforming to one or more of Formulas I-IV:
((Xaaneu−Xaa+)x(Xaaneu−Xaa−)y)n (I);
((Xaaneu−Xaa−)x(Xaaneu−Xaa+)y)n (II);
((Xaa+−Xaaneu)x(Xaa−−Xaaneu)y)n (III);
((Xaa−−Xaaneu)x(Xaa+−Xaaneu)y)n (IV);
wherein Xaaneu represents an amino acid residue having a neutral charge under physiological conditions;
Xaa+ represents an amino acid residue having a positive charge under physiological conditions;
Xaa− represents an amino acid residue having a negative charge under physiological conditions;
x and y are integers having a value of 1, 2, 3, or 4, independently;
and n is an integer having a value of 1-5.

7 more elements

Dependencies are inferred from the claim text.

Facts

Application: 16/394,990Filed 25 Apr 2019 · continuation
Priority: 22 Aug 2013
Published: US 2019/0247458 A115 Aug 2019
Granted: 22 Dec 2020
Term ends: Not estimatedThe source records don’t support an estimate.

Classification20 codes

A61K 38/10
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof: peptides having 12 to 20 amino acids
A61K 9/70
Medicinal preparations characterised by special physical form: web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
A61K 9/7007
Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug: drug-containing films, membranes or sheets
A61K 38/02
Medicinal preparations containing peptides: peptides of undefined number of amino acids; Derivatives thereof

Family

Application61/868,674Us provisional application · filed 22 Aug 2013
Application14/466,699Parent of this continuation · filed 22 Aug 2014
Application15/156,020Parent of this continuation · filed 16 May 2016
US 9,339,476 B2Parent of this continuation · filed 17 May 2016
Application15/818,602Parent of this continuation · filed 20 Nov 2017
US 9,821,022 B2Parent of this continuation · filed 21 Nov 2017
US 2019/0247458 A1Pre-grant publication · published 15 Aug 2019
US 10,314,886 B2Parent of this continuation
US 2015/0056263 A1Published application
US 2016/0317608 A1Published application
US 2018/0064782 A1Published application
US 10,869,907 B2This patent

From the US filing history. Foreign family members aren’t listed.

Timeline

Citations

Open elsewhere

Building an agent or pulling many patents? Use the API or MCP server instead of scraping pages. Get an API key