Isolated cells and populations comprising same for the treatment of CNS diseases
AssigneeRamot at Tel-Aviv University Ltd.
InventorsDaniel Offen, Merav Bahat-Stromza, Eldad Melamed
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Abstract
An isolated human cell and populations thereof is provided comprising at least one astrocytic phenotype and at least one mesenchymal stem cell phenotype, wherein the mesenchymal stem cell phenotype is not an astrocytic phenotype.
Claims10
An isolated cell population comprising human cells which express CD90, and secrete glial derived neurotrophic factor (GDNF), wherein a secretion of said GDNF is at least 2 times greater than a basal secretion of said GDNF in non-differentiated mesenchymal stem cells, wherein the cell population is non-genetically modified, and wherein the cell population has been differentiated ex vivo from human mesenchymal stem cells.
Dependencies are inferred from the claim text.