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US 10,869,887 B2Granted
Biologically relevant orthogonal cytokine/receptor pairs
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsKenan Christopher Garcia, Jonathan Sockolosky, Lora Picton
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Abstract
Engineered orthogonal cytokine receptor/ligand pairs, and methods of use thereof, are provided.
Claims26
An engineered human IL-2 polypeptide, which comprises amino acid substitutions, numbered relative to reference SEQ ID NO:4:
- E15S, E15T, E15Q, or E15H;
- H16Q;
- L19V or L19I;
- D20T, D20S, D20L or D20M;
- and
- M23L, M23S, M23V, M23A, or M23T;
- and optionally comprises Q22K, Q22N, R81D, R81Y, T51I or a combination thereof.
4 more elements
An engineered human IL-2 polypeptide that comprises a set of amino acid substitutions, numbered relative to reference SEQ ID NO:4:
- E15S;
- H16Q;
- L19V;
- D20L;
- M23A;
- and
- Q22K.
4 more elements
An engineered human IL-2 polypeptide that comprises a set of amino acid substitutions, numbered relative to reference SEQ ID NO:4:
- E1 5S;
- H16Q;
- L19V;
- D20L;
- and
- M23A.
3 more elements
Dependencies are inferred from the claim text.