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US 10,869,885 B2Granted
Tumor lysate loaded particles
AssigneeOrbis Health Solutions LLC
InventorThomas E. Wagner
Life of this patent
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Abstract
Dendritic cells containing tumor lysate loaded particles are prepared. The dendritic cells present tumor antigens to elicit the Major Histocompatibility Complex class I pathway and can be used as a vaccine to treat cancer, including ocular melanoma.
Claims9
A method for producing a tumor lysate loaded particle comprising:
- (i) contacting a suspension of yeast cell wall particles (YCWPs) with a tumor lysate, wherein contacting the suspension comprises:
- (a) incubating the suspension of YCWPs with the tumor lysate,
- (b) freeze-drying the suspension of YCWPs, and
- (c) washing the YCWPs, wherein steps (a)-(b) are repeated at least once with a step of adding water into the yeast cell particle before step (a) is repeated;
- and
- (ii) freeze-drying the suspension of YCWPs and the tumor lysate to produce a tumor lysate loaded particle.
3 more elements
Dependencies are inferred from the claim text.