Cyclodextrin based polymers, methods, compositions and applications thereof

A method for reducing lipid content in a cell or plasma membrane of a cell in a patient suffering from a kidney glomerular disease, the method comprising administering to the patient in need thereof, an effective amount of the cyclodextrin polymer having the following structure:

• wherein
• CD is a cyclodextrin moiety or a derivative thereof;
• L is a linker moiety, wherein L comprises the following structure:
• wherein Ar1 and Ar2 are each independently a 5- or 6-membered heteroaryl comprising 1, 2, 3 or 4 heteroatoms individually selected from N, O, and S, wherein Ar1 and Ar2 are optionally substituted with 1 to 3 R3 groups;
• Y is independently O, S, or NR4;
• m and p is each independently an integer from 1 to 10;
• R1 and R2 are each independently R4, OR4, SR4or R1 and R2 taken together with the carbon atom to which they are attached form a double bonded O, S, or NR4;
• R3 is selected from the group consisting of H, C1-C3 alkyl, C1-C3 alkyl sulfide, hydrazine, amine and halogen;
• and
• R4 is H or a saturated or unsaturated C1-C10 linear alkyl, saturated or unsaturated C1-C10 branched alkyl, or saturated or unsaturated C1-C10 cycloalkyl, each of which is optionally substituted;
• and
• n is from 4 to 1000.