Methods and compositions for topical delivery of prostaglandins to subcutaneous fat

A method for reducing subcutaneous fat in a subject, the method comprising topically administering to the subject a composition comprising a compound of Formula (I):

• or a pharmaceutically acceptable salt thereof, wherein:
• each instance of independently represents a single bond or a double bond which can be in the cis or trans configuration;
• A is optionally substituted C1-10 alkylene, optionally substituted C2-10 alkenylene, or optionally substituted C2-10 alkynylene, wherein the alkylene, alkenylene, or alkynylene group is optionally interrupted by one or more —O— or —S— groups;
• B is hydrogen, optionally substituted C3-7 carbocyclyl, optionally substituted 3-8-membered heterocyclyl, optionally substituted 5-14 membered-heteroaryl, optionally substituted C6-10 aryl, optionally substituted C1-30 alkyl, optionally substituted C2-30 alkenyl, or optionally substituted C2-30 alkynyl;
• X is —OR4, —SR4, or —N(R4)2, wherein each instance of R4 is independently hydrogen, optionally substituted C1-30 alkyl, optionally substituted C2-30 alkenyl, optionally substituted C2-30 alkynyl, —C(═O)R5, or —C(═O)OR5, wherein R5 is optionally substituted C1-30 alkyl, optionally substituted C2-30 alkenyl, or optionally substituted C2-30 alkynyl, or two R4 groups are joined to form an optionally substituted 3-8-membered heterocyclyl or optionally substituted 5-14-membered heteroaryl ring;
• Z is ═O, ═S, or ═NRZ, wherein RZ is selected from hydrogen, an amino protecting group, —OH, substituted hydroxyl, optionally substituted C1-10 alkyl, optionally substituted C2-10 alkenyl, optionally substituted C2-10 alkynyl, optionally substituted C3-7 carbocyclyl, optionally substituted 3-8-membered heterocyclyl, optionally substituted C6-10 aryl, or optionally substituted 5-14-membered heteroaryl, or Z represents two hydrogen atoms;
• and
• one of R1 and R2 is ═O, —OH, or a —O(CO)R6 group and the other one is —OH or —O(CO)R6, or R1 is ═O and R2 is H, wherein R6 is an optionally substituted C1-20 alkyl, optionally substituted C2-20 alkenyl, optionally substituted C2-20 alkynyl, or —(CH2)mR7, wherein m is 0 or an integer of between 1-10, inclusive, and R7 is optionally substituted C3-7 carbocyclyl, optionally substituted 3-8-membered heterocyclyl, optionally substituted C6-10 aryl, or optionally substituted 5-14-membered heteroaryl;
• and
• wherein the composition further comprises a fatty acid.