Methods and compositions for treating viral diseases
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsShirit Einav, Rina Barouch-Bentov, Gregory Neveu, Amotz Zivav
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Abstract
The invention provides a method for treating viral infections and coinfections through the use of inhibitory agents that prevent a unique viral structural protein motifs from binding to host proteins from the clathrin adaptor proteins family and subsequently preventing viral replication.
Claims8
A method of inhibiting assembly or budding of Dengue virus, comprising contacting a host cell that is infected with Dengue virus with sunitinib or a pharmaceutically acceptable salt of sunitinib, wherein the sunitinib inhibits adaptor-associated kinase 1 (AAK1), thereby inhibiting assembly or budding of the Dengue virus.
Dependencies are inferred from the claim text.