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US 10,869,856 B2Granted
Substituted phenylpyrrolecarboxamides with therapeutic activity in HIV
AssigneesNew York Blood Center, Inc., The United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsAsim Kumar Debnath, Francesca Curreli, Peter D. Kwong, Young Do Kwon
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Abstract
Substituted phenylpyrrolecarboxamide compounds such as those represented by Formula A can be used in the treatment of HIV infection and related conditions.
Claims12
A compound represented by Formula 1:
- wherein R4, R5, R6, R7, R8, R9, R10, R12, R13, and R14 are independently H, a halide, or a substituent having a molecular weight of 15 Da to 150 Da and consisting of 2 to 5 chemical elements, wherein the chemical elements are independently C, H, O, N, S, P, F, Cl, Br, or I;
- R11, R15, and R15a are independently H, optionally substituted C1-6 alkyl, optionally substituted carbamimidoyl, optionally substituted C1-6 aryl, or optionally substituted C1-6 heteroaryl, the optional substituent having a molecular weight of 15 Da to 150 Da and consisting of 2 to 5 chemical elements, wherein the chemical elements are independently C, H, O, N, S, P, F, Cl, Br, or I;
- R16 is H or C1-6 hydrocarbyl;
- and
- Y is a bond or C1-3 alkyl.
2 more elements
Dependencies are inferred from the claim text.