Compositions and methods for treating autism spectrum disorders
OwnerPaul Talalay, Andrew Zimmermaninventors
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Abstract
The instant disclosure features, among other things, compositions and methods for treating an autism spectrum disorder in a human. The compositions comprise an effective amount of: (1) an isothiocyanate (e.g., sulforaphane or a derivative thereof) or (2) a glucosinolate, and optionally, an enzyme, to thereby treat an autism spectrum disorder and/or reduce the severity of at least one symptom of the disorder. Methods for preparing such compositions are also featured.
Claims22
A method for treating an autism spectrum disorder in a human, the method comprising administering to the human daily a composition comprising an effective amount of an isothiocyanate, to thereby treat the disorder, wherein the effective amount is:
- between 25 and 75 μmol if the human weighs 100 pounds or less;
- between 75 and 125 μmol if the human weighs between 101 to 199 pounds;
- or between 125 and 175 μmol if the human weighs more than 200 pounds.
A method for treating an autism spectrum disorder in a human, the method comprising administering to the human an effective amount of an isothiocyanate to thereby treat the disorder, wherein the human has not experienced a seizure within one year prior to administering the isothiocyanate.
A method for treating an autism spectrum disorder in a human, the method comprising administering to the human:
- (a) an effective amount of an isothiocyanate to thereby treat the disorder;
- and (b) an effective amount of an anti-seizure drug.
A method for treating an autism spectrum disorder in a human, the method comprising administering to the human an effective amount of an isothiocyanate to thereby treat the disorder, wherein the human is not concurrently being treated with a drug associated with increased risk of seizure.
A method for treating an autism spectrum disorder in a human, the method comprising:
- (i) administering to the human an effective amount of an isothiocyanate to thereby treat the disorder;
- and
- (ii) monitoring the human for the occurrence of seizures.
A method for treating an autism spectrum disorder in a human, the method comprising administering to the human an effective amount of an isothiocyanate to thereby treat the disorder, wherein the isothiocyanate is to be administered in conjunction with a reduced calorie diet.
Dependencies are inferred from the claim text.