Targeting NUR77 for mitigating perinatal neuroinflammation
AssigneeUnited States Government as represented by the Secretary of the Army
InventorsNicholas M. Ieronimakis, Andrew S. Thagard, Sarah M. Estrada, Peter Napolitano
Life of this patent
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Abstract
Compositions and methods of inhibiting Nur77 in a subject for treatment of perinatal neuroinflammation, preterm labor, or preterm birth are provided.
Claims21
A method of treating or inhibiting preterm birth of a fetus caused by abnormal expression of Nur77, which comprises administering to the fetus an effective amount of one or more Nur77 antagonists.
A method of treating or inhibiting a disease or disorder selected from preterm labor, preterm birth, perinatal neuroinflammation, a perinatal neurological injury, a vascular injury, a neurodevelopmental disability, and cerebral palsy in a subject in need thereof, which comprises reducing or inhibiting expression of Nur77 or reducing or inhibiting Nur77 receptor signaling in the subject by administering to the subject an effective amount of one or more Nur77 antagonists, wherein the disease or disorder is caused by abnormal expression of Nur77.
Dependencies are inferred from the claim text.