US 10,869,841 B2 · Nanoscale coatings for encapsulation of biological entities

Abstract

Methods, systems, and devices are disclosed for encapsulating biological entities with preservation of their biological activity. In one aspect, a method of encapsulating a biological entity includes templating a biocompatible material onto a biological structure to form a coating structure enclosing the biological structure, the coating structure having a size in the nanometer range, in which the coated biological structure preserves its biological activity within the coating structure. In some implementations of the method, the biological structure includes a virus and the biocompatible material includes silica.

Claims10

Dependent claims

A bioactive virus delivery device, comprising:

an interior polymer material and virus, wherein the polymer material is bound to the surface of the virus via an electrostatic interaction;
and
an exterior silica gel matrix formed directly on the surface of the interior polymer material and virus to envelope, encapsulate, and preserve biological activity of the virus, wherein an outer surface of the silica gel matrix comprises a secondary functionalization, wherein the exterior silica gel matrix does not include the interior polymer material, and wherein encapsulation of the virus by the silica gel matrix protects the virus from immune recognition and neutralization during a viral therapy.

Dependencies are inferred from the claim text.

Facts

Application

16/255,709Filed 23 Jan 2019 · division

Priority

18 Apr 2013

Published

US 2019/0151253 A123 May 2019

Granted

22 Dec 2020

Term ends

Not estimatedThe source records don’t support an estimate.

Classification9 codes

A61K 9/5192
Nanocapsules; Nanoparticles: processes
A61K 9/5115
Excipients; Inactive ingredients: inorganic compounds
A61K 9/5146
Organic macromolecular compounds; Dendrimers: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g.…
A61K 35/76
Microorganisms or materials therefrom: viruses; Subviral particles; Bacteriophages

Family

Application61/813,612Us provisional application · filed 18 Apr 2013

PCT/US2014/034723Parent of this division · filed 18 Apr 2014

US 2019/0151253 A1Pre-grant publication · published 23 May 2019

Application14/785,611Parent of this division

US 2016/0067191 A1Published application

US 10,869,841 B2This patent

From the US filing history. Foreign family members aren’t listed.

Nanoscale coatings for encapsulation of biological entities

Life of this patent

Nanoscale coatings for encapsulation of biological entities

Life of this patent

Abstract

Claims10