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US 10,869,822 B2Granted
Compositions for treatment of dermatological diseases and conditions and methods of use thereof
AssigneeDermaMedics, LLC
InventorBryan B. Fuller
Life of this patent
Estimating the term…
Abstract
Compositions containing an effective dermatological disease-treating or dermatological condition-treating active agent and a pharmaceutically-acceptable carrier or vehicle are disclosed. Methods of using the compositions are also disclosed.
Claims20
A transdermal composition for topical administration to a subject having a dermatological disease or dermatological condition, comprising:
- an effective dermatological disease-treating or dermatological condition-treating amount of an active agent comprising soluble ethyl vanillin and/or a salt thereof, wherein the soluble ethyl vanillin retains its stability in the transdermal composition for at least 3 months, and wherein the soluble ethyl vanillin and/or a salt thereof is formed by dissolving solid ethyl vanillin and/or a salt thereof in non-aqueous solvent;
- and
- a pharmaceutically-acceptable carrier or vehicle effective in carrying or enabling passage of the active agent into the epidermis or dermis of the skin of the subject where the active agent has its effect on the dermatological disease or dermatological condition;
- and
- wherein the transdermal composition is non-aqueous and is absent emulsifiers.
2 more elements
A method of inhibiting production of at least one matrix metalloproteinase (MMP) in a subject's skin, the method comprising:
- topically administering an effective amount of a transdermal composition to a portion of the subject's skin, wherein the transdermal composition comprises:
- an active agent comprising at least one of soluble ethyl vanillin and a salt thereof, wherein the at least one of soluble ethyl vanillin a salt thereof is formed by dissolving at least one of solid ethyl vanillin and a salt thereof in non-aqueous solvent;
- and
- a pharmaceutically-acceptable carrier or vehicle effective in carrying or enabling passage of the active agent into the epidermis or dermis of the skin of the subject where the active agent has its effect on the at least on MMP;
- and
- wherein the transdermal composition is non-aqueous and is absent emulsifiers.
3 more elements
A method of treating a dermatological condition in a subject's skin, the method comprising:
- topically administering an effective amount of a transdermal composition to a portion of the subject's skin which is affected by a dermatological condition, wherein the transdermal composition comprises:
- an active agent comprising at least one of soluble ethyl vanillin and a salt thereof, wherein the at least one of soluble ethyl vanillin and a salt thereof is formed by dissolving at least one of solid ethyl vanillin and a salt thereof in non-aqueous solvent;
- and
- a pharmaceutically-acceptable carrier or vehicle effective in carrying or enabling passage of the active agent into the epidermis or dermis of the skin of the subject where the active agent has its effect on the at least one dermatological condition;
- and
- wherein the transdermal composition is non-aqueous and is absent emulsifiers;
- and
- wherein the dermatological condition is selected from the group consisting of inflammation, rosacea, allergic contact dermatitis, irritant contact dermatitis, seborrheic dermatitis, radiation dermatitis, erythema, psoriasis, atopic dermatitis, eczemas, actinic keratosis, acne, scarring, aging, and alopecia areata.
5 more elements
Dependencies are inferred from the claim text.