Endovascular stent grafts and methods of using said stent grafts
AssigneeRheinisch-Westfälische Technische Hochschule (RWTH) Aachen
InventorsAndreas Greiner, Stefan Jockenhövel, Andrij Pich, Larissa Hussmann, Valentine Gesché
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Abstract
AN endovascular stent graft including a hydrogel capable of retarded swelling when coming into contact with blood upon implantation in a patient is provided. Methods for the treatment of aneurysms and the prevention of ischemic neurological damage, in particular spinal cord damage, in patients receiving aneurysm repair procedures, using said endovascular stent grafts is also provided.
Claims23
An endovascular stent graft comprising an area having one or more through holes coated at least partially with a hydrogel capable of retarded reduction of the diameter of or retarded occlusion of said through holes by swelling upon implantation in a subject, wherein the retarded reduction or retarded occlusion occurs over a time course of one to four weeks.
A tubular shunt, wherein the inner walls of said shunt are coated at least partially with hydrogel capable of retarded swelling upon implantation in a subject and thereby reducing the diameter of said tubular shunt or closing said tubular shunt, wherein the retarded swelling occurs over a time course of one to four weeks.
An endovascular stent graft comprising an area having one or more through holes coated at least partially with a hydrogel capable of retarded reduction of the diameter of or retarded occlusion of said through holes by swelling upon implantation in a subject wherein said hydrogel comprises a polymer including a three-dimensional network of crosslinked polymer chains comprised of poly(ethylene glycol) methyl ether methacrylate (PEGMEMA) polymer chains having the general formula (I)
- wherein R1 is H or a linear or branched, substituted or unsubstituted alkyl group;
- R2 is a linear or branched, substituted or unsubstituted alkyl group or a functional group;
- and n is an integer of from about 6 to about 45;
- and
- said PEGMEMA polymer chains are crosslinked by at least an acrylate-based crosslinker comprising an internal disulfide moiety.
Dependencies are inferred from the claim text.