Body fluid leakage detection aqueous composition
AssigneesMagle Chemoswed Holding AB, Universität Heidelberg
InventorsHenrik Johansson, Peter Schuisky, Thomas Pausch, Thilo Hackert
Life of this patent
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Abstract
A body fluid leakage detection aqueous composition, for use e.g. in intraoperative pancreatic fluid leakage detection. The composition comprises a gelling agent, increasing the viscosity of the composition, and buffering species, the composition thereby being buffered. The gelling agent is cross-linked α-glucan microspheres. Further, the composition comprises a pH-indicator. The pH of the composition is at least 0.1 pH units lower, or higher, than a pKa of the pH-indicator.
Claims20
A body fluid leakage detection aqueous composition, wherein the composition is a pancreatic fluid leakage detection aqueous composition, the composition comprising a gelling agent, increasing the viscosity of the composition, wherein the gelling agent is cross-linked α-glucan microspheres, and buffering species, the composition thereby being buffered, wherein the composition further comprises a pH-indicator selected from the group consisting of bromothymol blue, phenol red, anthocyanins, and neutral red, wherein the pH of the composition is at least 0.1 pH units lower than a pKa of the pH-indicator, wherein the pH of the composition is in the range of 4 to 6, and wherein the pKa of the pH-indicator is in the range of 6 to 8.
A method for detecting pancreatic fluid leakage in conjunction with pancreatic surgery, the method comprising:
- applying a pancreatic fluid leakage detection aqueous composition to a tissue surface of the pancreas during pancreatic surgery, wherein the composition comprises a gelling agent, increasing the viscosity of the composition, wherein the gelling agent is cross-linked α-glucan microspheres, and buffering species, the composition thereby being buffered, wherein the composition further comprises a pH-indicator, wherein the pH of the composition is at least 0.1 pH units lower than a pKa of the pH-indicator, wherein the pH of the composition is in the range 4 to 6, and wherein the pKa of the pH-indicator is in the range 6 to 8;
- and
- detecting and localizing any leakage of pancreatic fluid on the tissue surface of the pancreas by a change in color of the pancreatic fluid leakage detection aqueous composition.
Dependencies are inferred from the claim text.