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US 10,865,811 B2Granted
Engineered tissue substitute system
AssigneeThe University of British Columbia
InventorsAziz Ghahary, Ryan Hartwell
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Abstract
Compositions and methods of preparation and use are provided for an engineered tissue substitute system comprising collagen, glycosaminoglycan and hydrogel in a cross-linked matrix. The compositions may be further lyophilized and reconstituted with a physiological fluid prior to use in methods, such as in the treatment of wounds, tissue engineering and cell transplantation.
Claims25
A lyophilized powder composition, the composition comprising:
- (a) collagen, wherein the collagen is at a concentration of between 3-10 mg/ml;
- (b) glycosaminoglycan, wherein the ratio of the glycosaminoglycan to collagen is a weight ratio from about 4:1 to about 8:1;
- (c) a biocompatible small molecule cross-linker of collagen and glycosaminoglycan;
- (d) a hydrogel, wherein the hydrogel is 0.01%-1.0% w/vol of the final composition;
- and
- (e) a biocompatible, small-molecule, hydrogel cross-linker.
3 more elements
Dependencies are inferred from the claim text.