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US 10,865,447 B2Granted
Biomarker signature method, and apparatus and kits therefor
AssigneeImmunexpress Pty Ltd
InventorsRichard Bruce Brandon, Leo Charles McHugh
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AssigneeImmunexpress Pty Ltd
InventorsRichard Bruce Brandon, Leo Charles McHugh
Estimating the term…
The present invention discloses methods, kits, and apparatus as well as reagents and compositions associated therewith for deriving an indicator for use in diagnosing the presence, absence or degree of at least one condition in a biological subject or in prognosing at least one condition in a biological subject. Also disclosed is a biomarker signature for use in diagnosing the presence, absence or degree of at least one condition in a biological subject or in prognosing at least one condition in a biological subject. The present invention further discloses methods, kits and apparatus, as well as reagents and compositions associated therewith, for identifying biomarkers for use in a biomarker signature.
A composition comprising a mixture of a DNA polymerase, whole peripheral blood leukocyte cDNA from a subject with a clinical sign of systemic inflammatory response syndrome (SIRS), wherein the whole peripheral blood leukocyte cDNA comprises a basic leucine zipper transcription factor (BATF) cDNA and a retinitis pigmentosa GTPase regulator interacting protein 1 (RPGRIP1) cDNA and the composition further comprises for each of up to 6 cDNAs, which comprise the BATF cDNA and RPGRIP1 cDNA, (1) two oligonucleotide primers that hybridize to opposite complementary strands of the cDNA, and (2) an oligonucleotide probe that comprises a reporter molecule and that hybridizes to the cDNA, wherein the oligonucleotide probe is a real-time polymerase chain reaction probe.
Dependencies are inferred from the claim text.