Optical detection for bio-entities

An integrated circuit device comprising:

• an optical signal conduit disposed on a first semiconductor substrate;
• a surface treated structure disposed over the first semiconductor substrate, the surface treated structure in communication with the optical signal conduit to receive an optical signal from the optical signal conduit;
• a cap configured to form a capped area, wherein the optical signal conduit extends from outside the capped area to inside the capped area, wherein the surface treated structure is disposed within the capped area;
• and
• a fluidic channel, wherein a first side of the fluidic channel is formed on the first semiconductor substrate and a second side of the fluidic channel is formed on the cap, the cap being coupled to the first semiconductor substrate.