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US 10,865,442 B2Granted
Common line selector valve for a system
AssigneeIllumina, Inc.
InventorBradley Kent Drews
Life of this patent
Estimating the term…
Abstract
A system may include a flow cell to support analytes of interest; a selector valve coupled to the flow cell to select a flow path through the flow cell from a plurality of flow paths; a pump coupled to the flow cell to displace fluids through the selected flow path during an analysis operation; and control circuitry coupled to the selector valve to command the selector valve to select the selected flow path.
Claims18
A system comprising:
- a plurality of flow paths to fluidically connect with a flow cell to support analytes of interest when the flow cell is mounted in the system;
- a flow path selector valve coupled to the flow paths, the flow path selector valve to select between the flow paths;
- a pump to fluidically connect with the flow cell when the flow cell is mounted in the system and to displace fluids through one of the flow paths selected by the flow path selector valve during an analysis operation;
- and
- control circuitry operatively coupled to the flow path selector valve, the control circuitry having one or more processors and a memory to store computer-executable instructions which, when executed by the one or more processors, control the one or more processors to command the flow path selector valve to select the selected flow path, wherein the plurality of flow paths comprise a first flow path coupled to a first channel of the flow cell and a second flow path coupled to a second channel of the flow cell and wherein the flow path selector valve is adjustable between a first state in which the flow path selector valve selects the first flow path, a second state in which the flow path selector valve selects the second flow path, and a third state in which the flow path selector valve selects both the first flow path and the second flow path.
2 more elements
A system comprising:
- a reagent selector valve to select a reagent from a plurality of reagents in accordance with an analysis protocol;
- a flow cell to support analytes of interest;
- a flow path selector valve fluidically interposed between the reagent selector valve and the flow cell, the flow path selector valve to select a flow path through the flow cell from a plurality of flow paths through the flow cell, and to direct the selected reagent through the selected flow path in accordance with the analysis protocol;
- a pump that is fluidically connected with the flow cell, the pump to displace the selected reagent through the selected flow path in accordance with the analysis protocol;
- and
- control circuitry operatively coupled to the flow path selector valve, the control circuitry having one or more processors and a memory to store computer-executable instructions which, when executed by the one or more processors, control the one or more processors to cause the flow path selector valve to select the selected flow path, wherein:
- the plurality of flow paths comprise a first flow path through one channel of the flow cell and a second flow path through a second channel of the flow cell,
- the flow path selector valve comprises at least one moveable portion, and
- the at least one moveable portion is moveable into a first position that selects the first flow path but not the second flow path, a second position that selects the second flow path but not the first flow path, and a third position that selects both the first and second flow paths.
6 more elements
A method comprising:
- controlling, using control circuitry, a flow path selector valve fluidly upstream of a flow cell to select one or more flow paths through the flow cell from a plurality of flow paths through the flow cell;
- and
- pumping, using a pump, a reagent through the one or more selected flow paths in accordance with an analysis protocol, wherein the plurality of flow paths comprises a first flow path through one channel of the flow cell and a second flow path through a second channel of the flow cell, wherein the second flow path is different from the first flow path, and wherein the flow path selector valve is adjustable between a first state in which the flow path selector valve selects the first flow path, a second state in which the flow path selector valve selects the second flow path, and a third state in which the flow path selector valve selects both the first flow path and the second flow path.
A method comprising:
- controlling a flow path selector valve fluidly upstream of a flow cell to select a flow path through the flow cell from a plurality of flow paths through the flow cell;
- displacing a reagent through the selected flow path in accordance with an analysis protocol, wherein the plurality of flow paths comprises a first flow path through one channel of the flow cell, a second flow path through a second channel of the flow cell, and a third flow path that includes both the first and the second flow paths, wherein the second flow path is different from the first flow path;
- controlling the flow path selector valve to select the third flow path;
- and
- displacing the reagent through the third flow path by simultaneously:
- displacing a first portion of the reagent through the first flow path and the first channel of the flow cell;
- and
- displacing a second portion of the reagent through the second flow path and the second channel of the flow cell.
5 more elements
Dependencies are inferred from the claim text.