Back to results
US 10,865,387 B2Granted
Methods of obtaining pancreatic endocrine cells
AssigneeThe University Court of the University of Aberdeen Regent Walk
InventorsKevin Docherty, Hilary Margaret Docherty, Maria Joao Marques De Lima, Kenneth Ross Muir, John Joseph Casey
Life of this patent
Estimating the term…
Abstract
The present invention relates to methods of producing pancreatic endocrine cells and uses of the cells obtained using the methods. The method utilises inhibitors or combinations of factors to provide increased quantities of endocrine material, for example for transplantation purposes.
Claims13
A method for ex-vivo reprogramming comprising:
- a) providing pancreatic cells to be reprogrammed,
- b) reprogramming the pancreatic cells, comprising:
- (i) treating the pancreatic cells with PAX4, PDX1, MAFA and NGN3 transcription factors and
- (ii) inhibiting ARX expression and/or function
- c) thereby obtaining beta-like cells that express insulin mRNA.
2 more elements
Dependencies are inferred from the claim text.