Stable iron oligosaccharide compound
AssigneePharmacosmos Holding A/S
InventorHans Andreasen
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Abstract
The invention relates to an iron oligosaccharide compound with improved stability comprising a hydrogenated oligosaccharide in stable association with ferric oxyhydroxide, the content of dimer saccharide in said hydrogenated oligosaccharide being 2.9% by weight or less, based on the total weight of the hydrogenated oligosaccharide. In further aspects is provided a process for preparing said compound as well as the use of said compound for preparation of a composition for treatment of iron deficiency anaemia.
Claims28
A process for preparing a mixture of hydrogenated dextran oligosaccharides, comprising:
- (a) hydrolysing a polysaccharide so as to reduce its molecular weight,
- (b) fractioning the oligosaccharide of (a) according to molecular weight, the fractioning including a procedure of purification, which procedure is continued until the content of dimer saccharide in the purified fraction of oligosaccharide has been reduced to 2.9% by weight or less, based on the total weight of the oligosaccharide, and
- hydrogenating the oligosaccharide resulting from step (a) or step (b)
- wherein said oligosaccharide produced in step (b) comprises a mixture of hydrogenated dextran oligosaccharides having the following molecular weight distribution:
- (i) a weight average molecular weight (Mw) between 500 and 3,000 Daltons,
- (ii) a number average molecular weight (Mn) above 500 Daltons;
- (iii) 90% by weight of said hydrogenated dextran oligosaccharides have molecular weights of less than 3,500 Daltons, and
- (iv) the Mw of the 10% by weight fraction containing the hydrogenated dextran oligosaccharides having the highest molecular weights is below 4,500 Daltons.
A process for preparing a mixture of hydrogenated dextran oligosaccharides, comprising:
- (a) hydrolysing a polysaccharide so as to reduce its molecular weight,
- (b) fractioning the oligosaccharide of (a) according to molecular weight, the fractioning including a procedure of purification, which procedure is continued until the content of dimer saccharide in the purified fraction of oligosaccharide has been reduced to 2.3% by weight or less, based on the total weight of the oligosaccharide, and
- hydrogenating the oligosaccharide resulting from step (a) or step (b),
- wherein said oligosaccharide produced in step (b) comprises a mixture of hydrogenated dextran oligosaccharides having the following molecular weight distribution:
- (i) a weight average molecular weight (Mw) between 500 and 1,600 Daltons,
- (ii) a number average molecular weight (Mn) is above 500 Daltons,
- (iii) 90% by weight of said hydrogenated dextran oligosaccharides have molecular weights of less than 2,700 Daltons,
- (iv) the Mw of the 10% by weight fraction of the hydrogenated dextran oligosaccharides having the highest molecular weights is below 3,200 Daltons, and
- (vi) the content of monomer saccharide in said hydrogenated oligosaccharide is 0.5% by weight or less, based on the total weight of the hydrogenated oligosaccharide.
Dependencies are inferred from the claim text.