Back to results
US 10,865,253 B2Granted
Rodent bispecific heterodimeric proteins
AssigneeGenmab A/S
InventorsAran F. Labrijn, Joyce I. Meesters, Janine Schuurman, Paul Parren, Anthony Armstrong, Matthew Bunce, Mark Chiu, Thomas Nesspor, Adam Zwolak
Life of this patent
Estimating the term…
Abstract
Novel rodent bispecific heterodimeric proteins, such as rodent bispecific antibodies, in vitro method for producing such, and uses thereof.
Claims14
A bispecific antibody comprising first and second IgG heavy and light chain constant and variable domains (regions) wherein:
- the first IgG heavy chain comprising a first Fc region, said first Fc region comprising a first CH3 domain;
- and
- the second IgG heavy chain comprising a second Fc region, said second Fc region comprising a second CH3 domain,
- wherein the first and second Fc regions originate from a rodent species, and wherein
- (a) the first CH3 domain comprises at position 370 and Arg at position 409, and
- (b) the second CH3 domain comprises Leu at position 405 when using EU numbering index.
3 more elements
Dependencies are inferred from the claim text.