Process for the preparation of 5-(4-cyanophenoxy)-1,3-dihydro-1-hydroxy-[2,1]-benzoxaborole and polymorphs thereof
AssigneeMsn Laboratories Private Limited, R&D Center
InventorsThirumalai Rajan Srinivasan, Eswaraiah Sajja, Venkat Reddy Ghojala, Markandeya Bekkam
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Abstract
The present invention relates to process for the preparation of 5-(4-cyano phenoxy)-1,3-dihydro-1-hydroxy-[2,1]-benzoxaborole represented by the following structural formula-1 and polymorphs thereof. The present invention also relates to salts of 5-(4-cyano phenoxy)-1,3-dihydro-1-hydroxy-[2,1]-benzoxaborole and process for their preparation and their use in the preparation of pure compound of the formula-1.
Claims10
A process for the preparation of 5-(4-cyanophenoxy)-1,3-dihydro-1-hydroxy-[2,1]-benzoxaborole compound of formula-1, comprising;
- a) reacting 2-halo-5-hydroxybenzyl acetate compound of general formula-4
- with 4-halobenzonitrile compound of general formula-5
- wherein, ‘X’ represents halogens such as F, Cl, Br & I;
- to obtain 2-halo-5-(4-cyanophenoxy)benzyl acetate compound of general formula-6, and
- b) converting the compound of general formula-6 into compound of formula-1.
Dependencies are inferred from the claim text.