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US 10,865,207 B2Granted
Compounds for imaging Tau protein aggregates
AssigneesAC Immune SA, Life Molecular Imaging SA
InventorsHeiko Kroth, Jérôme Molette, Hanno Schieferstein, Andre Müller, Heribert Schmitt-Willich, Mathias Berndt, Felix Oden
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Abstract
The present invention relates to novel compounds of the formula (I) that can be employed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imaging.
Claims26
A compound of the formula (I)
- as well as pharmaceutically acceptable salts, hydrates, solvates, prodrugs and polymorphs thereof;
- wherein R1 is 18F and R2 is H.
A compound of the formula (I)
- as well as pharmaceutically acceptable salts, hydrates, solvates, prodrugs and polymorphs thereof;
- wherein R1 is F and R2 is H.
A compound of the formula (I)
- as well as pharmaceutically acceptable salts, hydrates, solvates, prodrugs and polymorphs thereof;
- R1 is LG, wherein LG is nitro, halogen or trimethyl ammonium;
- R2 is H or PG;
- PG is a protecting group;
- LG is a leaving group.
2 more elements
Dependencies are inferred from the claim text.