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US 10,865,201 B2Granted
Bicyclic compounds useful as GPR120 modulators
AssigneeValo Health, Inc.
InventorsBrian Raimundo, Elena S. Koltun, John Griffin, Eric Stangeland
Life of this patent
Estimating the term…
Abstract
Provided herein are compounds, compositions including them, and methods of modulating GPR120 activity and treating diseases mediated by GPR120 by administering such compounds and compositions.
Claims20
A compound of formula:
- wherein
- each X independently is CH, CR3, or N;
- Y is SO2;
- Z is —CH2—, —CH(CH3)—, —C(CH2CH2)—(cyclopropano), —(CO)CH2—, or —CHCH—;
- U is CH2, —CH(CH3)—, —C(CH3)2—, or —CH2CH2—;
- R1 is an optionally substituted alkyl group, an optionally substituted 3-7 membered cycloalkyl or heterocyclyl group, an optionally substituted 6-membered aryl group, an optionally substituted 5- or 6-membered heteroaryl group, an optionally substituted 5,6- or 6,6-membered bicyclic heteroaryl group, or an optionally substituted bicyclic aryl group;
- R2 is an optionally substituted 3-7 membered cycloalkyl or heterocyclyl group, an optionally substituted 6-membered aryl group, an optionally substituted 5- or 6-membered heteroaryl group, an optionally substituted 5,6- or 6,6-membered bicyclic aryl or heteroaryl group, or an optionally substituted bicyclic aryl group;
- and
- R3 is a halogen, or an optionally substituted alkyl or alkoxy group.
6 more elements
A compound of the structure
- or a tautomer thereof, or an isotopomer thereof, or a stereoisomer thereof, or a pharmaceutically acceptable salt of each thereof, or a prodrug thereof, or a pharmaceutically acceptable solvate of each of the foregoing.
Dependencies are inferred from the claim text.