Heterocyclic antiestrogens

A compound of Formula I

• or salts or stereoisomers thereof wherein,
• R1 is mono or di-substitution on ring A and is selected from a group consisting of, —OR3, halogen, —C1-6 haloalkyl, —OC1-6 haloalkyl, —CN, —N(R3)2,—NR3SO2R3, —NR3CHO, —NR3COR3, —OC(O)R3, —OC(O)N(R3)2, —OP(O)(OH)2 and —OC(O)OR3 wherein R3 at each occurrence is selected from hydrogen, C1-6 linear, branched or cyclic alkyl and C1-6 linear, branched or cyclic haloalkyl;
• R2 is mono or di-substitution and is a halogen;
• R4 is selected from hydrogen and —C1-5 alkyl;
• L is selected from C1-7 linear or branched alkyl;
• R7 and R8 are absent or independently selected from hydrogen and C1-5 alkyl;
• R9 and R10 together with the nitrogen atom to which they are attached forms a 4 to 5 membered ring optionally containing 1 to 2 additional heteroatoms selected from oxygen, nitrogen or sulfur;
• and the ring is optionally substituted with one or more group selected from halogen, —OR6, —N(R6)2 and R6 wherein R6, at each occurrence is selected from a group comprising hydrogen, C1-20 linear, branched or cyclic alkyl optionally interrupted with one or more radicals independently selected from —O—, —NR5—, —S—, —SO—,—S(O)2—, —CR5═CR5—, —C≡C—, —NR5CO—, —CONR5—, —NR5CONR5—, NR5C(O)O— and —OC(O)O—;
• optionally, R6 is further substituted with one or more groups selected from a group comprising halogen, —OR12, —N(R12)2, and —COOR12, —CON(R12)2 or —CON(R12)OH;
• wherein R12 at each occurrence is selected from hydrogen or C1-6 linear, branched or cyclic alkyl;
• is a double or a triple bond;
• R13 is selected from a group comprising —R14, —OR14, halogen, —C1-6 haloalkyl, —OC1-6 haloalkyl, —CN, —N(R14)2, —NR14SO2R14, —NR14CHO, —NR14COR14, —OC(O)R14, —OC(O)N(R14)2, —OP(O)(OH)2 and —OC(O)OR14 wherein R14 at each occurrence is selected from hydrogen, and C1-6 linear, branched or cyclic alkyl;
• and
• X is oxygen.