Therapeutically active bicyclic-sulphonamides and pharmaceutical compositions

A compound having the structure of Formula I,

• wherein:
• R1 represents an unsubstituted or a substituted pyrazolyl or isoxazolyl ring;
• R2, R3, R4 and R5 are independently selected from the group consisting of hydrogen, alkyl, hydroxyalkyl and alkyl-O-alkyl;
• provided that either R2 and R3 or R4 and R5 are linked or taken together to form a bridge between the carbon atoms to which R2 and R3 or R4 and R5 respectively are directly linked wherein the heterocyclic N-containing ring shown in Formula I has a meaning selected from the group consisting of:
• wherein Z is selected from CRviRvii, O, or can be absent;
• Rii, Riii, Riv and Rv are independently selected from the group consisting of hydrogen and alkyl;
• Rvi and Rvii are independently selected from the group consisting of hydrogen and alkyl;
• R6 is independently selected from the group consisting of hydrogen, alkyl, haloalkyl, cyano and halogen;
• X is selected from the group consisting of O, S and NRx;
• RX is independently selected from the group consisting of hydrogen and alkyl;
• R7 is selected from the group consisting of phenyl, pyrimidinyl, pyrazinyl, pyridazinyl, 1,3-benzoxazolyl, quinolinyl, and quinoxalinyl;
• or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, or racemic mixture thereof.