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US 10,865,193 B2Granted
Pyridone derivatives for the treatment of viral infections and further diseases
AssigneeJanssen Sciences Ireland Unlimited Company
InventorsDavid Craig McGowan, Pierre Jean-Marie Bernard Raboisson
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Abstract
This invention relates to pyridone derivatives, processes for their preparation, pharmaceutical compositions, and their use in therapy.
Claims16
A compound of formula (I)
- or a pharmaceutically acceptable salt, solvate or polymorph thereof, wherein
- R1 is C1-6 alkyl, optionally substituted by one or more substituents independently selected from the group consisting of aryl, halogen, OH, NH2, CO2H, CO2C1-3alkyl, C(O)NHC1-3alkyl, C(O)NHSO2C1-3alkyl, C1-3 alkyl, C3-6 cycloalkyl, SO2C1-3alkyl, S(O)C1-3alkyl, SO2NHC1-3alkyl, heterocycle, and CN;
- and
- R2, R3, R4, and R5 are independently selected from hydrogen, halogen, C1-3alkyl, C1-3 alkoxy, C3-6 cycloalkyl, aryl, —CF3 or heterocycle,
- provided that
- R2 is fused with R3 to form an aryl ring structure,
- R3 is fused with R4 to form an aryl ring structure, or
- R4 is fused with R5 to form an aryl ring structure.
5 more elements
A method of preparing a compound of formula (I), said method comprising reacting a compound of formula A
- with a compound of formula A-1
- to form the compound of formula B
- reducing the compound of formula B to form a compound of formula D
- reacting the compound of formula D with a compound of formula D-1
- to form a compound of formula (I)
- wherein R1 is C1-6 alkyl, optionally substituted by one or more substituents independently selected from the group consisting of aryl, halogen, OH, NH2, CO2H, CO2C1-3alkyl, C(O)NHC1-3alkyl, C(O)NHSO2C1-3alkyl, C1-3alkyl, C3-6 cycloalkyl, SO2C1-3alkyl, S(O)C1-3alkyl, SO2NHC1-3 alkyl, heterocycle, and CN;
- and
- R2, R3, R4, and R5 are each independently selected from the group consisting of hydrogen, halogen, C1-3alkyl, C1-3alkoxy, C3-6cycloalkyl, aryl, —CF3 and heterocyclyl,
- provided that
- R2 is fused with R3 to form an aryl ring structure,
- R3 is fused with R4 to form an aryl ring structure, or
- R4 is fused with R5 to form an aryl ring structure.
9 more elements
Dependencies are inferred from the claim text.