Heterocyclic compounds useful as modulators of TNF alpha

A compound of Formula (I):

• or a salt thereof, wherein:
• A is CR1;
• B is CR3;
• D is CR4;
• X is —NR8—;
• L1 is a bond or —CH2;
• L2 is a bond, —CH2—, —CH(CH3)—, —C(CH3)2—, —CH(CH2F)—, —CH(CHF2)—, —CH(CF3)—, —CH(CH2CH3)—, —CH(CH2CH2F)—, —CH(CH2CHF2)—, —CH(CH2CF3)—, —CH(CH2CH2OH)—, —CH(CH2N(CH3)2)—, —CH(C(CH3)2OH)—, —CH(CH2CH═CH2)—, —CH(CH3)CH2—, —CH(cyclopropyl)-, —CH(CH(CH3)2)—, —CH(C(CH3)2F)—, —CH(CH3)CH2CH2—, —CH(CH3)CH2C(OH)(phenyl)-, cyclopropyl, or cyclobutyl;
• Z is a cyclic group selected from C3-6 cycloalkyl, cyclopentenyl, phenyl, furanyl, imidazolyl, indolinyl, isoquinolinyl, isothiazolyl, isoxazolyl, oxazolyl, piperidinyl, pyrazinyl, pyrazolyl, pyridinyl, pyrimidinyl, thiazolyl, and thiophenyl, wherein said cyclic group is substituted with zero to 3 Ra;
• R1 is H or F;
• R2 is (i) F, Cl, or Br;
• or (ii) dihydropyridinonyl, phenyl, piperidinyl, pyrazinyl, pyrazolyl, pyridinyl, or pyrimidinyl, each substituted with zero to 3 R1a;
• R3 is H, F, or Cl;
• R4 is H, F, or Cl;
• R5 is H, —OH, —CH3, —CH2OH, —CH2NH2, —CH2N3, —C(O)OH, —C(O)NH(CH3), —C(O)N(CH3)2, —CH2NH(dimethylphenyl), —C(O)NH(pyridinyl), —C(O)NH(phenyl), or —CH2O(pyridinyl);
• R6 is F, Cl, or —CH3;
• R8 is H, —CH3, or —CH2CH3;
• each R1a is independently F, —CN, —CH3, —CH2CH3, —CH2OH, —C(CH3)2OH, —CH(OH)CH2OH, —CH(CH3)(OH)CH2OH, —C(CH2F)2OH, —C(CH3)2NHC(O)CH3, —C(O)NH2, —C(O)NHCH2CH2CH2CH2NH2, —C(O)NHCH3, —C(O)OH, —CH(C(O)OCH3)CH2NH2, —CH(CH2OH)NHC(O)CH3, —CH(NH2)CH2OH, —CH(NH2)CH2C(O)OH, —CH2CH(NH2)C(O)OH, —CH2NH(CH2CH3), —CH2NHC(O)CH3, —CH2NHC(O)NH2, —CH(OH)CH2NH(CH3), —NH(CH3), —NHCH2CH2OH, —NHCH2CH(OH)CH2OH, —NHCH2C(CH3)2OH, —NHCH(CH2OH)2, —NHCH2C(O)NH2, —NHCH2C(O)OH, —NHCH(CH3)C(O)NH2, —NHCH2CH(OH)CH2OH, —N(CH3)C(O)CH═CH2, —OCH2CH3, —S(O)2CH3, —S(O)2NH(CH3), —CH2(azetidinyl), —CH2(piperazinyl), —CH2(butoxycarbonylpiperazinyl), —CH(OH)(cyclopropyl), —CH(OH)CH2(morpholinyl), —CH(OH)CH2(carboxypyrrolidinyl), —NH(carbamoylcyclopropyl), C3-6 cycloalkyl substituted with 1 to 2 substituents independently selected from —OH, —NH2, —NHC(O)NH2, —NHC(O)CH3, —NHCH2CH2OH, —NHS(O)2CH3, —CH2OH, —C(O)OH, and —C(O)CH3;
• hydroxybutanonyl, hydroxypyrrolidinyl, carboxypyrrolidinyl, methoxycarbonylpyrrolidinyl, hydroxypropylpyrrolidinyl, hydroxypyranyl, hydroxyoxetanyl, hydroxymethylmorpholinyl, dioxohydroxytetrahydrothiopyranyl, piperidinyl substituted with 1 to 2 substituents independently selected from —NH2, —C(O)OH, —CH2C(O)OH, —C(CH3)2OH, and —C(O)OCH2CH3;
• piperazinyl substituted with zero or 1 substituent selected from —CH2OH, —CH2CN, —CH2C(O)OH, —CH2C(O)OCH3, —CH2C(O)NH2, —CH2C(O)NHCH3, —CH(C(O)OCH3)CH2NHC(O)CH3, —CH(C(O)OH)CH2NH2, —CH2C(O)NHS(O)2CH3, —CH2C(O)NHCH2C(O)OH, —CH(C(O)OH)CH2NHC(O)CH3, —CH(C(O)OH)CH2NHC(O)OC(CH3)3, —C(O)OH, —C(O)CH(CH3)OH, —C(O)CH(NH2)CH2C(O)OH, —C(O)CH(NH2)CH2OH, —C(O)CH2CH2C(O)OH, —C(O)CH═CH2, —C(O)C≡CH, —CH2(tetrazolyl), and pyrrolidinonyl;
• piperazinonyl, carboxymethylpiperazinonyl, morpholinyl, dioxothiomorpholinyl, carboxyazabicyclo[3.2.1]octanyl, or pyridinyl;
• each Ra is independently F, Cl, Br, —CN, —OH, —CH3, —CH2CH3, —CH═CH2, —C≡C(phenyl), —CF3, —CH2OH, —CH2CH2OH, —CH(CH3)OH, —CH2CH2CH2OH, —C(CH3)2OH, —CH(OH)CH2OH, —CH2CH(OH)CH2OH, —C(CH3)(OH)CH2OH, —CH(OH)CH(CH3)CH2CH(CH3)2, —CH2NH2, —CH(NH2)CH2OH, —CH(NH2)CH(CH3)CH2CH2CH3, —CH2C(O)NH2, —CH2CH2C(O)NH2, —CH2(phenyl), —C(O)CH3, —C(O)NH2, —C(O)NH(CH3), —C(O)NH(CH2CH3), —C(O)N(CH3)2, —C(O)CH(CH3)CH2CH2CH3, —C(O)(pyrazolyl), —C(O)(pyridinyl), —C(O)NH(phenyl), —C(O)OH, —CH2C(O)OH, —CH2CH2C(O)OH, —C(O)OCH3, —C(O)OC(CH3)3, —CH═NOH, —OCHF2, —OCH3, —OCF3, —OCH2CH2OH, —OCH2CH2CH2OH, —OCH2C(O)OH, —OCH═CH2, —NH2, —NHC(O)OC(CH3)3, —NHCH(CH3)CH2CH(CH3)CH3, —S(O)2CH3, —S(O)2NH2, —S(O)2CH2CH2C(O)OCH3, —S(O)2(methylpyrazolyl), oxazolidinonyl, cyclopentenyl, imidazolidine-2,4-dionyl, imidazolinonyl, methylimidazolyl, indolyl, morpholinonyl, morpholinyl, pyrazinyl, pyridazinyl, methylpyridazinyl, dimethoxypyridazinyl, pyrrolidinonyl, pyrrolidinyl, pyrrolo[2,3-b]pyridinyl, tetrahydropyridinyl, tetrazolyl, methyltetrazolyl, thiazolyl, triazolyl, methyltriazolyl, phenyl substituted with zero to 2 substituents independently selected from F, Cl, —CN, —CH3, —NH2, —OCH3, and —OC(O)C(CH3)3;
• pyrazolyl substituted with zero to 2 substituents independently selected from —CH3, —CH2CH3, —CHF2, —CF3, —C(O)OH, —CH2C(O)OH, —CH2C(CH3)2OH, —CH2(phenyl), and —CH2CH2(morpholinyl);
• pyridinyl substituted with zero to 2 substituents independently selected from —CN, —CH3, —CH2CH3, —OCH3, —NH2, —NH(CH3), —N(CH3)2, and —C(O)(morpholinyl);
• or pyrimidinyl substituted with zero to 1 substituent selected from —CH3, —C(CH3)2OH, —OCH3, —NH2, —N(CH3)2, cyclopropyl, and morpholinyl.