Compounds, reagents, and uses thereof
AssigneeMetabolon, Inc.
InventorsQibo Zhang, Anne M. Evans
Life of this patent
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Abstract
The present invention provides a compound of formula (I) or a salt thereof and their use as a biomarker in assessing or monitoring kidney function in a subject, determining predisposition to developing reduced kidney function, classifying a subject according to level of kidney function, diagnosing or monitoring chronic kidney disease. Compositions and method of making of the compound of formula (I) are also described.
Claims19
A compound represented by the following formula:
- or a salt thereof, wherein the compound is at least 60%, 70%, 80%, 90%, 95%, 99%, 99.5% or 99.9% pure.
A method of determining the level of a compound represented by the following formula:
- or a salt thereof, in a subject comprising:
- (1) preparing an analytical sample from a biological sample obtained from the subject;
- (2) determining the level of the compound using chromatography, mass spectrometry, enzyme-linked immunosorbent assay (ELISA), antibody linkage, immunoblotting, immunohistochemistry (IHC), other immunochemical methods, or a combination thereof.
A kit comprising a compound represented by the following formula:
- or a salt thereof, and instructions for measuring the level of the compound in a biological sample.
A method for preparing a compound represented by the following formula:
- or a salt thereof, comprising reacting a compound represented by the following formula:
- or a salt thereof, with a methylation reagent CH3X or (CH3)2SO4, wherein X is Cl, Br, I or OSO2CF3.
Dependencies are inferred from the claim text.