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US 10,865,176 B2Granted
Small molecule modulators of microRNA-34a
AssigneeThe Chinese University of Hong Kong
InventorYangchao Chen
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Abstract
The present invention provides methods for identifying compounds that act as miR-34a modulators. The present invention also provides miR-34a modulators and compositions containing the modulators. The present invention further provides methods for treating diseases by administration of miR-34a modulators.
Claims12
A method of inhibiting human cancer cell proliferation comprising contacting a human cancer cell with an effective amount of:
- wherein R1-R5 is CH3, and R6 is H, and
- wherein the effective amount is an amount effective to increase miRNA-34a expression in the human cancer cell and wherein p53 gene in the human cancer cell is wild-type or mutated but not deleted.
Dependencies are inferred from the claim text.