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US 10,864,549 B2Granted
Half-coating method for nanoparticles
AssigneeSogang University Research Foundation
InventorsJeong Woo Choi, Jin Ho Yoon, Sang Uk Kim
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Abstract
The present invention provides a method and a kit for half coating nanoparticles. According to the present invention, nanoparticles can be half coated in a relatively simple and economical process that can replace complicated processes, such as chemical synthesis, of a conventional Janus nanoparticle-preparing method.
Claims18
A kit comprising:
- (a) a substrate;
- (b) a first oligonucleotide self-assembled on the substrate;
- (c) a second oligonucleotide partially hybridized with a terminal of the first oligonucleotide;
- (d) single-stranded DNA nuclease or a double-stranded DNA nuclease;
- and
- (e) nanoparticles half-coated with a chemical substance complex, wherein the chemical substance complex is cucibit [8] Uril (CB), Trp Gly Gly (WGG peptide), and 5,5′Bis(mercaptomethyl)-2,2′-bipyridine.
3 more elements
A method for half-coating of nanoparticles, the method comprising:
- (a) self-assembling a first oligonucleotide on a substrate;
- (b) hybridizing a second oligonucleotide, complementary to a terminal region of the first oligonucleotide, with the first oligonucleotide;
- (c) conjugating nanoparticles to the second oligonucleotide;
- (d) coating an exposed surface of the nanoparticles with cucibit [8] Uril (CB), Trp Gly Gly (WGG peptide) and 5,5′Bis(mercaptomethyl)-2,2′-bipyridine;
- and
- (e) treating the product in step (d) with single-stranded DNA nuclease or a double-stranded DNA nuclease to obtain half-coated nanoparticles.
3 more elements
Dependencies are inferred from the claim text.