Polypeptide and hyaluronic acid coatings

A method for preparing a device comprising a polyelectrolyte coating having biocidal activity, the method comprising:

• (a) providing a device;
• (b1) depositing on the surface of said device
• (i) at least one polycationic layer consisting of at least one polyarginine consisting of n repetitive arginine units, wherein n is an integer comprised between 2 and 10, and then
• ii) at least one polyanionic layer consisting of hyaluronic acid, or
• (b2) depositing on the surface of said device ii) and then i) as defined above, and repeating b1) and/or b2) so that the polyelectrolyte coating comprises 40 to 200 polycationic layers and 40 to 200 polyanionic layers.

A method of preventing a bacterial infection in an individual undergoing an implantation of an implantable device comprising:

• i) providing an implantable device comprising a polyelectrolyte coating having biocidal activity, wherein said polyelectrolyte coating comprises:
• (a) at least one polycationic layer consisting of at least one polyarginine consisting of n repetitive arginine units, wherein n is an integer comprised between 2 and 10 and wherein the individual polyarginine chains are mobile and/or diffuse within the polyelectrolyte coating, and
• (b) at least one polyanionic layer consisting of hyaluronic acid,
• wherein the polyelectrolyte coating comprises 40 to 200 polycationic layers and 40 to 200 polyanionic layers, and
• ii) implanting said implantable device in the individual, wherein said implantable device prevents a bacterial infection.