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US 10,864,284 B2Granted
RNA transcription vector and uses thereof
AssigneeVrije Universiteit Brussel
InventorsCarlo Heirman, Kristiaan Thielemans
Life of this patent
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Abstract
The present invention in general relates to an improved RNA transcription vector, which is very suitable for the production of mRNA for in vivo therapeutic purposes. The improvements in the vector in particular reside in the presence of a transcription enhancer and a nuclear retention element.
Claims8
An RNA molecule comprising a translation enhancer (TE) which is 89% identical to the nucleotide sequence set forth in SEQ ID NO:
- 1, a translatable nucleic acid sequence, and a nuclear retention sequence which is identical to the nucleotide sequence set forth in SEQ ID NO:
- 4.
Dependencies are inferred from the claim text.