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US 10,864,272 B2Granted
Scintillator nanocrystal-containing compositions and methods for their use
AssigneeThe Regents of the University of California
InventorsMilan T. Makale, Wolfgang J. Wrasidlo, Santosh Kesari, Joanna McKittrick, Gustavo A. Hirata Flores, Olivia Graeve
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Abstract
There are provided, inter alia, compositions including a scintillator nanocrystal linked to a chemical agent moiety through a scintillator-activated photocleavable linker, and methods of use thereof.
Claims21
A composition, comprising:
- (i) a scintillator nanocrystal comprising (Y1-xPrx)3Al5O12, where x is 0.01;
- (ii) a chemical agent moiety comprising doxorubicin;
- and
- (iii) a scintillator nanocrystal-activated photocleavable linker comprising:
- wherein said linker operably links said scintillator nanocrystal and said chemical agent moiety.
2 more elements
A composition comprising:
- (i) a scintillator nanocrystal comprising (Y1-xPrx)3Al5O12, where x is 0.0075, 0.01, 0.0125, 0.015, or 0.0175;
- (ii) a chemical agent moiety comprising an anti-cancer drug moiety;
- and
- (iii) a scintillator nanocrystal-activated photocleavable linker comprising:
- wherein n3 is an integer from 0 to 5;
- and L1 is bond, —C(O)—, —C(O)O—, —O—, —S—, —NH—, —C(O)NH—, —NHC(O)—, —S(O)2-, —S(O)NH—, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene;
- wherein said linker operably links said scintillator nanocrystal and said chemical agent moiety.
4 more elements
Dependencies are inferred from the claim text.