Synthetic vaccines against Streptococcus pneumoniae serotype 2

A saccharide of general formula (I)

• V*-Ux+3-Ux+2-Ux+1-Ux-O-L-NH2 (I)
• wherein
• x is an integer selected from 1, 2, 3 and 4;
• V*- represents H-, H-Ux-, H-Ux+1-Ux-, H-Ux+2-Ux+1-Ux- or H-Ux+3-Ux+2-Ux+1-Ux-;
• L is selected from
• —CH2—, —(CH2)2—, —(CH2)3—, —(CH2)4—, —(CH2)5—, —(CH2)6—, —(CH2)7—, —(CH2)8—, —(CH2)9—, —(CH2)10—, —CF2—, —(CF2)2—, —(CF2)3—, —(CF2)4—, —(CF2)5—, —(CF2)6—, —(CF2)7—, —(CF2)8—, —(CF2)9—, —(CF2)10—, —(CH2)2—O—(CH2)2—, —CH2—O—(CH2)3—, —(CH2)3O—CH2—, —CH2—O—(CH2)2—, —(CH2)2O—CH2—, —(CH2)3—O—(CH2)2—, —(CH2)2—O—(CH2)3—, —(CH2)4—O—CH2—, —CH2—O—(CH2)4—, -La-, -La-Le-, -La-Lb-Le-, -La-Lb-Ld-Lc-Le-, and -La-Ld-Le-;
• wherein
• -La- is selected from:
• —(CH2)o—, —(CF2)o—, —(CH2—CH2—O)o—C2H4—, —(CH2—CH2—O)o—CH2—, —(CR10R11)o—,
• -Lb- and -Lc- are independently of each other selected from:
• —O—, —NH—C(O)—NH—, —NH—C(S)—NH—, —NH—C(O)—, —C(O)—NH—, —NH—C(O)—O—, —NR9—, —NR18—, —SO2—,
• -Ld- represents —(CH2)q—, —(CF2)q—, —(CR12R13)q—, —(CH2—CH2—O)q—C2H4—, —CH2—CH2—O)q—CH2—,
• -Le- is selected from:
• —(CH2)p1—, —(CF2)p1—, —C2H4—(O—CH2—CH2)p1—, —CH2—(O—CH2—CH2)p1—, —(CH2)p1—O—(CH2)p2—, —(CR14R15)p1—, —(CR14R15)p1—O—(CR21R22)q2—,
• R9 and R18 are independently of each other selected from:
• —CH3, —C2H5, —C3H7, and —C(O)CH3;
• R10, R11, R12, R13, R14, R15, R16, R17, R19, R20, R21 and R22 are independently of each other selected from:
• —H, —F, —Cl, —CH3, —C2H5, —C3H7, —C5H9, —C6H13, —OCH3, —OC2H5, —CH2F, —CHF2, —CF3, —C(O)—NH2, —SCH3, —SC2H5, —NHC(O)CH3, —N(CH3)2 and —N(C2H5)2;
• o, q, p1 and p2 are independently of each other an integer selected from 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10;
• or a pharmaceutically acceptable salt thereof.