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US 10,864,258 B2Granted
Method for treating pancreatic cancer with Toxoplasma gondii vaccine
AssigneeTrustees of Dartmouth College
InventorsDavid J. Bzik, Barbara A. Fox, Kiah L. Sanders
Life of this patent
Estimating the term…
Abstract
Attenuated Toxoplasma gondii mutants and methods using the same as vaccines in the prevention or treatment pancreatic cancer are provided.
Claims2
A method for treating pancreatic cancer comprising administering at least six doses of an irradiated pancreatic tumor cell to a subject in need of treatment over a period of 36 days, wherein the irradiated tumor cell harbors an effective amount of an attenuated mutant of Toxoplasma gondii comprising a knockout mutation of orotidine 5′-monophosphate decarboxylase;
- a knockout mutation of uridine phosphorylase;
- and nucleic acids encoding one or more of annexin A2, plectin-1, fetoacinar pancreatic protein, or tubulin tyrosine ligase-like family member 4, thereby treating the subject's pancreatic cancer.
Dependencies are inferred from the claim text.