Lipid hydrolysis therapy for atherosclerosis and related diseases
AssigneeChildren's Hospital Medical Center
InventorsGregory A. Grabowski, Hong Du
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Abstract
The present invention comprises a method to diminish and/or eliminate atherosclerotic plaques, in mammals, through direct and indirect treatment of these plaques, in situ, using suitable substances which are capable of lipid removal, primarily through hydrolysis, either by a catalytic or stoichiometric process, wherein the substance targets receptors in and/or on the cell which lead to uptake into the lysosome. Such substances used to diminish and/or eliminate atherosclerotic plaques are generally comprised of lipid hydrolyzing proteins and/or polypeptides.
Claims3
A sterile, aqueous solution consisting of
- a) human lysosomal acid lipase (hLAL) protein;
- b) human serum albumin;
- c) one or more buffers;
- and
- d) water.
Dependencies are inferred from the claim text.