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US 10,864,251 B2Granted
Peptides of syndecan-1 for inhibiting angiogenesis
AssigneeWisconsin Alumni Research Foundation
InventorsAlan C. Rapraeger, DeannaLee M. Beauvais
Life of this patent
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Abstract
The present invention provides a peptide derived from the extracellular domain of syndecan-1 that inhibits angiogenesis.
Claims20
A method of inhibiting αvβ3 or αvβ5 integrin activation by syndecan-1, comprising contacting a cell expressing an αvβ3 or αvβ5 integrin molecule with a polypeptide segment consisting of 32 to 100 amino acid residues and comprising SEQ ID NO:21, whereby the αvβ3 or αvβ5 integrin activation is inhibited.
Dependencies are inferred from the claim text.