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AssigneeSami Labs Limited
InventorsMuhammed Majeed, Kalyanam Nagabhushanam, Sarang Bani, Anjali Pandey
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The present invention discloses a composition comprising Allium sativum extract standardized to contain not less that 0.3% w/w S-allylcysteine, Beta vulgaris extract standardized to contain not less than 2% w/w nitrates, Nigella sativa extract standardized to contain 0.1%-5% w/w thymoquinone, about 0.01%-10% w/w thymohydroquinone, about 20%-95% w/w fatty acids, about 0.001%-3% w/w α-hederin or hederagenin, and Terminalia arjuna extract standardized to contain 3% w/w arjunoglucosides for use a prostaglandin transporter inhibitor. The invention also discloses the use of the aforementioned composition in the therapeutic management of hypertension and cardiovascular complications.
A method for inhibiting prostaglandin transporter in mammalian cells, said method comprising step of bringing into contact mammalian cells expressing prostaglandin transporter with a composition essentially consisting of 30-60% w/w Allium sativum extract is standardized to contain not less than 0.3% S-allylcysteine, 10-30% w/w Beta vulgaris extract standardized to contain not less than 2% nitrates, 5-15% w/w Nigella sativa extract standardized to contain 0.1%-5% w/w thymoquinone, about 0.01%-10% w/w thymohydroquinone, about 20%-95% w/w fatty acids, about 0.001%-3% w/w α-hederin or hederagenin, and 10-30% w/w Terminalia arjuna extract standardized to contain 3% w/w arjunoglucosides.
Dependencies are inferred from the claim text.