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US 10,864,233 B2Granted
Compositions and methods for treatment of cardiovascular disorders
AssigneeCorMatrix Cardiovascular, Inc.
InventorRobert G Matheny
Life of this patent
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Abstract
Methods for treating cardiovascular disorders that include administration of an ECM based composition to damaged cardiovascular tissue in conjunction with a treatment remedy, such as ventricular assistance and transmyocardial revascularization (TMR), which induces enhanced bioremodeling of the damaged cardiovascular tissue and regeneration of new cardiovascular tissue and associated structures with site-specific structural and functional properties.
Claims9
A method for treating damaged cardiovascular tissue of a subject, the method comprising the steps of:
- providing a mixed liquid exosome augmented extracellular matrix (ECM) composition, said exosome augmented ECM composition comprising acellular ECM from a mammalian tissue source and a plurality of exogenous exosomes isolated from mesenchymal stem cells (MSCs),
- said acellular ECM adapted to induce a first level of stem cell proliferation, bioremodeling of damaged cardiovascular tissue and regeneration of new cardiovascular tissue, when said acellular ECM is disposed proximate said damaged cardiovascular tissue,
- said plurality of exogenous exosomes adapted to induce a second level of stem cell proliferation, bioremodeling of said damaged cardiovascular tissue and regeneration of new cardiovascular tissue, when said plurality of exogenous exosomes is disposed proximate said damaged cardiovascular tissue;
- providing a left ventricular assist device (LVAD) that supports heart function by reducing mechanical load on a left ventricle of a subject's heart when said LVAD is in communication with said subject's left ventricle;
- and
- delivering said exosome augmented ECM composition proximate said damaged cardiovascular tissue associated with said subject's cardiovascular disorder in conjunction with providing said support of said subject's heart function with said LVAD, wherein, a third level of stem cell proliferation, bioremodeling of said damaged cardiovascular tissue and regeneration of new cardiovascular tissue is induced, said third level of induced stem cell proliferation, bioremodeling of said damaged cardiovascular tissue and regeneration of new cardiovascular tissue being greater than the sum of said first level of induced stem cell proliferation, bioremodeling of said damaged cardiovascular tissue and regeneration of new cardiovascular tissue, and said second level of induced stem cell proliferation, bioremodeling of said damaged cardiovascular tissue and regeneration of new cardiovascular tissue.
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Dependencies are inferred from the claim text.