Use of microRNA-188-5p for treating Alzheimer's disease
AssigneeSeoul National University R&Db Foundation
InventorsHye Sun Kim, Kihwan Lee, Hyunju Kim
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Abstract
The present invention relates to a use of microRNA(miR)-188-5p which can be used for treatment of Alzheimer's disease, and the pharmaceutical composition comprising miR-188-5p as an active ingredient of the present invention can inhibit the expression of NRP2 protein when it is added to a subject having Alzheimer's disease, thereby restoring the reduced density of dendritic spines and enhancing synaptic transmission, and thus it can prevent or treat Alzheimer's disease effectively.
Claims12
A method for preventing or treating Alzheimer's disease comprising:
- administering an effective amount of a composition comprising miR-188-5p to a subject in need thereof.
A method for restoring cognitive function related to Alzheimer's disease comprising:
- administering an effective amount of miR-188-5p to a subject in need thereof.
Dependencies are inferred from the claim text.