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US 10,864,222 B1Granted
Beta-lactamase inhibitors, formulations, and uses thereof
AssigneesUniversity of South Florida, The Regents of the University of California
InventorsYu Chen, Orville Antonio Pemberton, Adam Renslo, Priyadarshini Jaishankar
Life of this patent
Estimating the term…
Abstract
Provided herein are heterocyclic compounds and pharmaceutical formulations that can be used to treat bacterial infections. Also provided herein are methods of making and using the heterocyclic compounds and pharmaceutical formulations.
Claims18
A compound according to Formula 1,
- wherein X1 is O, CH, or N—R8, wherein R8 is CH3 or H;
- wherein X2 is PO(OH)2;
- wherein X3 is H;
- wherein X4 is C or N+;
- wherein X5 is C;
- wherein R1 is CH3, Br, F, O−, or OCH3;
- wherein R2 is H;
- wherein R3 is H, CH3, F, or OCH3;
- wherein R4 is H;
- wherein R5 is H or ═O;
- and
- wherein R1 and R3 are not both CH3 if X1 is O, and wherein R3 is not OCH3 if X1 is O and R1 is CH3.
9 more elements
A pharmaceutical formulation comprising:
- an amount of a compound according to Formula 1
- wherein X1 is O, CH, or N—R8, wherein R8 is CH3 or H;
- wherein X2 is PO(OH)2;
- wherein X3 is H;
- wherein X4 is C or N+;
- wherein X5 is C;
- wherein R1 is CH3, Br, F, O−, or OCH3;
- wherein R2 is H;
- wherein R3 is H, CH3, F, or OCH3;
- wherein R4 is H;
- wherein R5 is H or ═O;
- and
- wherein R1 and R3 are not both CH3 if X1 is O, and wherein R3 is not OCH3 if X1 is O and R1 is CH3.
10 more elements
A method of treating a pathogenic bacterial infection in a subject in need thereof, the method comprising:
- administering, to the subject in need thereof having a pathogenic bacterial infection, an amount of a compound according to Formula 1
- wherein X1 is O, CH, or N—R8, wherein R8 is CH3 or H;
- wherein X2 is PO(OH)2;
- wherein X3 is H;
- wherein X4 is C or N+;
- wherein X5 is C;
- wherein R1 is CH3, Br, F, O−, or OCH3;
- wherein R2 is H;
- wherein R3 is H, CH3, F, or OCH3;
- wherein R4 is H;
- wherein R5 is H or ═O;
- and
- wherein both R1 and R3 are not both CH3 if X1 is O, and wherein R3 is not OCH3 if X1 is O and R1 is CH3.
10 more elements
Dependencies are inferred from the claim text.