US 10,864,207 B2 · Method of treating endothelial dysfunction

Abstract

The present invention herein discloses potent synergistic compositions of vasoactive mediators enhancers for improving vascular endothelial function. Particularly, the invention relates to synergistic nutritional composition comprising exogenous blend of N1-methyl nicotinamide chloride and standardized red spinach extract enriched with nitrate content along with pharmaceutically acceptable excipients, wherein N1-methyl nicotinamide salt and standardized red spinach extract enriched with nitrate content are present in the ratio of 1:0.5 to 1:8; and N1-methyl nicotinamide chloride and nitrate of standardized red spinach extract, are present in the ratio of 1:0.1 to 1:1. The present synergistic composition is useful for treating endothelial dysfunction such as hypertension, atherosclerosis, thrombosis, myocardial infarction, heart injury.

Claims9

Dependent claims

A method of treatment of endothelial dysfunction in a subject in need thereof, wherein the method comprising, oral administration of a therapeutically effective amount of a nutritional composition comprising a synergistic blend of N-1 methyl nicotinamide chloride and standardized red amaranth extract enriched with 9-12% by weight nitrate content with pharmaceutically acceptable excipients,

wherein the N-1 methyl nicotinamide chloride and the standardized red amaranth extract enriched with nitrate content are present in a weight ratio of 1:1 to 1:6;
and the N-1 methyl nicotinamide chloride and the nitrate content of the standardized red amaranth extract are present in a weight ratio of 1:0.1 to 1:0.6.

Dependencies are inferred from the claim text.

Facts

Application

16/733,131Filed 2 Jan 2020

Priority

IN 2019210000932 Jan 2019

Published

US 2020/0222383 A116 Jul 2020

Granted

15 Dec 2020

Term ends

Not estimatedThe source records don’t support an estimate.

Classification15 codes

A61K 31/455
Non condensed pyridines; Hydrogenated derivatives thereof: nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
A61K 9/0056
Mouth and digestive tract, i.e. intraoral and peroral administration: mouth soluble or dispersible forms; Suckable, eatable, chewable coherent…
A61K 31/5585
Having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes: having five-membered rings containing oxygen as the…
A61K 33/00
Medicinal preparations containing inorganic active ingredients

Method of treating endothelial dysfunction

Life of this patent

Method of treating endothelial dysfunction

Life of this patent

Abstract

Claims9