Parasiticidal compositions comprising fipronil at high concentrations
AssigneeBoehringer Ingelheim Animal Health USA Inc.
InventorsJames Pate, Natalya Shub
Life of this patent
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Abstract
The invention provides for spot-on formulations comprising fipronil in a high concentration for the treatment or prophylaxis of parasites of mammals and birds, and in particular, cats, dogs, horses, chickens, sheep and cattle with the aim of ridding these animals of all the parasites commonly encountered by birds and mammals. The invention also provides for effective and lasting destruction of ectoparasites, such as fleas, ticks, itch mites and lice, and of endoparasites, nematodes, such as filariae, and roundworms of the digestive tract of animals and humans.
Claims8
A topical veterinary composition comprising:
- (a) from about 16% to about 18% (w/v) fipronil;
- (b) optionally, about 5% to about 15% (w/w) (S)-methoprene;
- (c) about 14% to 18% (w/v) of a crystallization inhibitor which is a combination of polyvinylpyrrolidone and polyoxyethylene (20) sorbitan monooleate in a weight:weight ratio of about 2:1 to about 1.7:1;
- (d) an organic co-solvent selected from the group consisting of methanol, ethanol, and isopropanol;
- (e) an organic solvent which is butyl diglycol, dipropylene glycol n-butyl ether, ethylene glycol monoethyl ether, ethylene glycol monomethyl ether, dipropylene glycol monomethyl ether, liquid polyoxyethylene glycols, propylene glycol monomethyl ether, propylene glycol monoethyl ether, diethylene glycol monoethyl ether, or any combination thereof;
- and
- (f) optionally, about 0.01% to about 2.0% of an antioxidant wherein the organic solvent (e) is present in the overall composition in a proportion representing a compliment to 100% of the composition;
- wherein, the organic co-solvent to organic solvent is in a weight:weight ratio of between 1/15 and 1/2;
- and
- wherein composition results in less than 10 crystals when placed on a glass slide at 20° C. for 24 hours.
A topical veterinary composition comprising:
- (a) from about 16% to about 18% (w/v) fipronil;
- (b) optionally, about 5% to about 15% (w/w) (S)-methoprene;
- (c) about 14% to about 18% (w/v) of a crystallization inhibitor which is a combination of polyvinylpyrrolidone and polyoxyethylene (20) sorbitan monooleate in a weight:weight ratio of about 2:1 to about 1.8:1;
- (d) an organic co-solvent which is ethanol;
- (e) an organic solvent which is diethylene glycol monoethyl ether;
- and
- (f) optionally, about 0.01% to about 2.0% of an antioxidant wherein the organic solvent (e) is present in the overall composition in a proportion representing the compliment to 100% of the composition;
- wherein, the organic co-solvent to organic solvent is in a weight:weight ratio of between 1/15 and 1/2;
- and
- wherein composition results in less than 10 crystals when placed on a glass slide at 20° C. for 24 hours.
Dependencies are inferred from the claim text.