Metabolic therapy for wound healing
AssigneeUniversity of South Florida
InventorsDominic Paul D'Agostino, Shannon Kesl
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Abstract
Ketone supplementation, such as through use of precursors of beta-hydroxybutyrate (BHB) and acetoacetate (AcAc), increased blood levels of ketone bodies, increases blood flow and wound closure in ischemic young and aged fisher rats significantly earlier compared to standard diet in aged rats. In vitro experiments with ketone bodies demonstrate decreased mitochondrial and cytosolic ROS in young and aged primary human dermal fibroblasts (PHDF). Ketone bodies increased migration in young and aged PHDFs.
Claims20
A method of improving wound healing, comprising:
- orally, intragastrically, intraarterially, or intravenously administering at least one ketone source to a patient, in need thereof wherein the at least one ketone source includes 1,3-butanediol and is administered to obtain ketosis in the patient;
- wherein the patient has a wound, and
- wherein the patient is fed ad libitum and is not on a ketogenic diet.
A method of reducing or treating redox stress in wound repair, comprising:
- orally, intragastrically, intraarterially, or intravenously administering at least one ketone source to a patient, in need thereof wherein the at least one ketone source includes 1,3-butanediol and is administered to obtain ketosis in the patient;
- wherein the patient has a wound, and
- wherein the patient is fed ad libitum and is not on a ketogenic diet.
Dependencies are inferred from the claim text.