Conjugated polymer nanoparticles and manufacturing method thereof

A method of producing conjugated polymer nanoparticles for photothermal therapy comprising:

• dissolving a conjugated polymer and fatty acid in a solvent to prepare a first mix solution;
• mixing the first mix solution with a solution containing an amphiphile polymer to prepare a second mix solution;
• and
• conducting reaction of the second mix solution,
• wherein the conjugated polymer nanoparticles comprise a core consisting of the mixture of the conjugated polymer and the fatty acid, and a pharmaceutically active ingredient;
• and a shell surrounding the core and comprising the amphiphile polymer, and
• wherein:
• the fatty acid is selected from the group consisting of oleic acid, capric acid, caprylic acid, palmitic acid, lauric acid, myristic acid, arachidic acid, behenic acid, lignoceric acid, cerotic acid, and combinations thereof,
• the conjugated polymer is capable of being doped in the presence of HCI having a lower concentration than 10−3 M,
• the fatty acid is a phase change material which is present in a solid phase during the production of the conjugated polymer nanoparticles and can be melted by heat emitted from the conjugated polymer absorbing light, and
• the conjugated polymer of the conjugated polymer nanoparticles is capable of being doped at pH 1 to 8 with a dopant.