Tamper-resistant tablet providing immediate drug release

A tamper-resistant tablet comprising:

• (i) a matrix material in an amount of at least 40 wt.-% based on a total weight of the tablet;
• and
• (ii) a plurality of coated particulates in an amount of less than or equal to 60 wt.-% based the total weight of the tablet;
• wherein said coated particulates comprise a pharmacologically active compound and a physiologically acceptable polymer;
• wherein said pharmacologically active compound is selected from the group consisting of stimulants;
• wherein the physiologically acceptable polymer is a polyalkylene oxide having a weight average molecular weight of at least 500,000 g/mol;
• wherein the physiologically acceptable polymer is present in said coated particulates in an amount of at least 25 wt.-% based on a total weight of coated particulates;
• wherein the coated particulates comprise a coating comprising a coating material comprising a water-soluble polymer selected from the group consisting of cellulose esters, cellulose ethers, poly(meth)acrylates, vinyl polymers, and natural film formers;
• wherein said coated particulates form a discontinuous phase within the matrix material;
• wherein said coated particulates do not comprise a disintegrant;
• and wherein said coated particulates have a breaking strength of at least 300 N;
• said plurality of coated particulates releasing within 15 minutes at least 60% by weight of the plurality of coated particulates of pharmacologically active compound as monitored in 900 mL 0.1 HCL at 37° C., using a paddle apparatus at 50 rpm;
• and
• said tablet providing under in vitro conditions immediate release of the pharmacologically active compound in accordance with European Pharmacopoeia (Ph. Eur.).