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US 10,864,163 B2Granted
Therapeutic agents and delivery with microspheres
AssigneeUCL Business PLC
InventorRichard Michael Day
Life of this patent
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Abstract
The invention relates to methods for attaching therapeutic agents to structures produced by thermally induced phase separation as well as methods for coating devices and producing multi-layered microspheres.
Claims12
A method for attaching a therapeutic agent to a hydrophobic microsphere structure produced by thermally induced phase separation comprising:
- i) at least partly submerging the hydrophobic microsphere structure in a culture medium;
- ii) subsequently contacting the hydrophobic microsphere structure with a wetting agent that wets the hydrophobic microsphere structure, wherein the wetting agent is ethanol which is added to the culture medium to a concentration of from 10% to 30%;
- and
- iii) attaching the therapeutic agent to the hydrophobic microsphere structure.
1 more element
Dependencies are inferred from the claim text.